Developing nano medicines for rare genetic disorders. There are approximately 7,000 rare disorders worldwide. Each day more are being discovered. 95% of rare diseases have not one single FDA approved treatment. Glycomine develops therapeutics for diseases which have no treatment options. We focus on genetic disorders of protein and lipid glycosylation, which often cause severe debilitation in patients. There are 100 known glycosylation disorders. Glycomine is currently addressing 2 disorders of glycosylation: CDG-Ia and Ngly1 deficiency. Glycomine’s therapeutic approach relies on the design and construction of nano-vehicles for efficient delivery of replacement therapies into affected cells and tissues.