Vijay Ramani, Gladstone Institutes. “Single-Molecule Sequencing To Understand Genome Regulation”

Vijay Ramani

Vijay Ramani is interested in the mechanisms that control how genes are turned on or off in our cells. He develops molecular techniques that make it possible to monitor gene activity at the level of single cells and single molecules. With these techniques, Ramani and his team study how changes in genome organization affect gene activity, or how the same gene may produce different RNA molecules under different conditions. In turn, the team hopes to parlay this information into a better understanding of the molecular steps that lead to disease or maintain the pluripotency of stem cells.

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About the Speaker

Vijay Ramani, PhD, is an Assistant Investigator in the Gladstone Institute for Data Science and Biotechnology, and Assistant Professor of Biochemistry and Biophysics at the University of California, San Francisco (UCSF). Dr. Ramani’s curiosity-driven research group develops novel technologies to understand the molecular underpinnings of mammalian transcriptional regulation. Work in the Ramani Lab spans multiple areas of bioscience, including molecular biology, biochemistry, and computer science. Recent research has focused on advancing single-molecule DNA sequencing methods to understand how DNA is packaged within mammalian nuclei. This work has yielded mechanistic insight into the cell-, tissue- and human disease-specific dynamics of DNA structure within the context of the nucleoprotein complex called chromatin.

Dr. Ramani received his BSE in Chemical Engineering from Princeton University and his PhD in Genome Sciences working in Jay Shendure’s group at the University of Washington School of Medicine. Directly following completion of his PhD, Dr. Ramani received the prestigious Sandler Faculty Fellowship, allowing him to immediately start an independent research group at UCSF. In addition to the Sandler Faculty Fellowship, Dr. Ramani has been awarded the NIH Director’s New Innovator Award, the Searle Scholars Award, and in 2019 was named to Forbes Magazine’s 30 Under 30 in the Healthcare category.