Events

Cryo-electron microscopy (cryoEM) and cryo-electron tomography (cryoET) have emerged as powerful techniques for visualizing biological structures in vitro and in situ. Over the past decade, advances in specimen preparation, instrumentation, and data processing have made it possible to readily obtain high-resolution structures of isolated biological molecules and have opened up the potential for understanding the full molecular architecture of the cell. I will discuss the automation and streamlining of cryoET, combined with the use of machine learning approaches, which are crucial for unlocking the full potential of these methods and driving future progress in structural cell biology.

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About the Speaker

Bridget Carragher received her Ph.D. in Biophysics from the University of Chicago in 1987. She worked in a variety of positions, both in industry and academia before moving to the New York Structural Biology Center in 2015 to lead the Simons Electron Microscopy Center (SEMC), together with Clint Potter.

While at SEMC, Bridget and Clint directed the National Resource for Automated Molecular Microscopy (NRAMM), the National Center for CryoEM Access and Training (NCCAT), the National Center for In-situ Tomographic Ultramicroscopy (NCITU), and the Simons Machine Learning Center (SMLC). They also founded the company NanoImaging Services in 2007.

Bridget moved to in January 2023 to take up the role as Founding Technical Director of the Chan Zuckerberg Imaging Institute (CZII), now incorporated into Biohub. Our mission is to enable deep insights into the architecture of complex biological systems, at the molecular level, through the development and application of novel imaging technologies. A current grand challenge focus is to develop technologies and methodologies to image the molecular architecture of the cell using cryo electron tomography.