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First look at an enzyme target for antibacterial and cancer drugs

The veil has been lifted on an enzyme critical to the process of DNA transcription and replication and a prime target of antibacterial and anticancer drugs. James Berger and his research team have produced the first 3D images of a DNA-bound Type II topoisomerase responsible for untangling coiled strands of the chromosome during cell division.

First look at an enzyme target for antibacterial and cancer drugs

DNA-bound Type II topoisomerase

The veil has been lifted on an enzyme critical to the process of DNA transcription and replication and a prime target of antibacterial and anticancer drugs. James Berger and his research team have produced the first 3D images of a DNA-bound Type II topoisomerase responsible for untangling coiled strands of the chromosome during cell division. More