UCSF Bioengineering and Therapeutic Sciences Symposium

All symposium activities take place in the Robertson
Auditorium, Second Floor, William J. Rutter
Center, UCSF Mission Bay, 1675 Owens Street,
San Francisco, California.

8:30 a.m. ~ Registration and Continental
Breakfast

9:00 a.m. ~ Welcome
Kathy Giacomini, PhD, and Sarah Nelson, PhD, Professors;
Symposium Co-chairs; and Co-chairs, UCSF Department of
Bioengineering and Therapeutic Sciences
Mary Anne Koda-Kimble, PharmD, Professor of Clinical
Pharmacy and Dean, UCSF School of Pharmacy
Sam Hawgood, MBBS, Professor and Dean, UCSF School
of Medicine

9:40 a.m. ~ Session 1
Systems and Computational Biology and
Pharmacology
Moderator: Andrej Sali, PhD, Professor, UCSF Department
of Bioengineering and Therapeutic Sciences
Life emerges from an interplay between biological molecules,
which are organized in extensive networks of
interactions that are embedded in space and may change
with time. There is a close relationship between a network’s
architecture and its function. In this session, the speakers
will address how our understanding of the biological
networks can help therapeutical modulation of a network
and engineering networks with novel functions.
Systems Biology and Systems Medicine: Catalyzing
the Transition from Reactive to Proactive Medicine /
Leroy Hood, MD, PhD, President, Institute for Systems
Biology, Seattle, Washington
Molecular Networks / Chao Tang, PhD, Professor, UCSF
Department of Bioengineering and Therapeutic Sciences
Genomics as a Tool for Discovering New Small Molecules
from the Human Microbiome / Michael A.
Fischbach, PhD, Assistant Professor, UCSF Department of
Bioengineering and Therapeutic Sciences

10:55 a.m. ~ Break

11:05 a.m. ~ Session 2
Pharmacogenomics
Moderator: Deanna L. Kroetz, PhD, Professor, UCSF
Department of Bioengineering and Therapeutic Sciences
The contribution of genetic variation to variability in drug
response and toxicity is well recognized among clinical pharmacologists
and clinicians. In recent years, genetic markers
have been identified for the response or toxicity associated
with numerous drugs, including warfarin, irinotecan, 6-mercaptopurine,
abacavir, and clopidogrel. This session will
highlight the use of genomewide scans to further our understanding
of drug response pathways, our current knowledge
of genetic variation in noncoding regions of drug transporters,
and the use of admixture mapping to understand population
differences in disease risk and drug response.
Cancer Pharmacogenomics: The Fruits of Genomewide
Studies in Acute Lymphocytic Leukemia / William E. Evans,
PharmD, Director and Chief Executive Officer, St. Jude
Children’s Research Hospital, Memphis, Tennessee
Finding Function in ‘Junk DNA’ / Nadav Ahituv, PhD,
Assistant Professor, UCSF Department of Bioengineering and
Therapeutic Sciences
Genomics Approaches in Health Disparities / Esteban
González Burchard, MD, MPH, Associate Professor, UCSF
Department of Bioengineering and Therapeutic Sciences

12:15 p.m. ~ Session 3, Lunch
Enhancing Education and Research Partnerships
between the UCSF Department of
Bioengineering and Therapeutic Sciences and
Industry
Co-moderators: Susan Desmond-Hellmann, MD, MPH,
UCSF Chancellor and Regis B. Kelly, PhD, Director, California
Institute for Quantitative Biosciences
To facilitate translation of its discoveries to patient care, the
UCSF Department of Bioengineering and Therapeutic
Sciences must partner successfully with the private sector.
This session brings together key individuals from academia,
industry, and formerly from the FDA to discuss best practices
for enhancing partnerships. The department’s educational
outreach programs will also be discussed with an emphasis on
further shaping and extending current pioneering courses
sponsored by the department.
Agenda
Leslie Z. Benet, PhD, Professor, UCSF Department of
Bioengineering and Therapeutic Sciences
Ellen G. Feigal, MD, Adjunct Professor, UCSF Department
of Bioengineering and Therapeutic Sciences
Corey S. Goodman, PhD, Managing Director and Cofounder,
venBio, LLC, San Francisco, California
Carl C. Peck, MD, Adjunct Professor, UCSF Department of
Bioengineering and Therapeutic Sciences
George Scangos, PhD, President and Chief Executive
Officer, Exelixis, Inc., South San Francisco, California

2:05 p.m. ~ Break

2:15 p.m. ~ Session 4
Bioengineering
Moderator: Francis C. Szoka, PhD, Professor, UCSF
Department of Bioengineering and Therapeutic Sciences
Interactions between engineers and clinical scientists have
fueled numerous advances in the development of new treatment
strategies, as well as novel methods for delivering cell
and drug-based therapies. Critical areas of collaborative
research include the design of new probes that target specific
kinds of pathology, sensors for assessing biological activity,
and devices for more effective delivery of the agent to the
region of interest. This session will provide examples of how
bioengineering is contributing to translational research and
providing broader educational experiences to basic and
clinical scientists.
Education of Clinician Scientists in Bioengineering and
Therapeutic Sciences / Paul Yock, MD, Martha Meier
Weiland Professor of Medicine and Mechanical Engineering;
Director of the Center for Research in Cardiovascular
Interventions; and Director of the Stanford Biodesign Program,
Stanford University, Stanford, California
Modular, Multi-Functional Micelles to Target Pathological
Tissue / Matthew Tirrell, PhD, Professor and Chair,
Department of Bioengineering, University of California,
Berkeley, Berkeley, California
Nanotechnology for Therapeutic Devices / Tejal Desai,
PhD, Professor, UCSF Department of Bioengineering and
Therapeutic Sciences
A Quantum Leap for the Kidney / Shuvo Roy, PhD,
Associate Professor, UCSF Department of Bioengineering
and Therapeutic Sciences

3:55 p.m. ~ Closing Remarks
Kathy Giacomini, PhD, and Sarah Nelson, PhD,
Symposium Co-chairs and Co-chairs, UCSF Department of
Bioengineering and Therapeutic Sciences

4:05 p.m. ~ Poster Session and Reception
Moderators: Tanja Kortemme, PhD, Assistant Professor;
Patricia Babbitt, PhD, Professor; Su Guo, PhD, Associate
Professor—UCSF Department of Bioengineering and
Therapeutic Sciences
More than 30 posters are being presented, representing
research in bioengineering and therapeutic sciences at UCSF.
Awards for the best posters by a graduate student and
a postdoctoral researcher will be given at the reception.

4:50 p.m. ~ Adjourn