Core Research Facilities

QB3-Berkeley maintains these core facilities at Stanley Hall for the use of affiliated researchers:

Structure Determination

Central California 900 MHz NMR Spectrometer Facility
Directed by Professor David Wemmer, this Stanley Hall facility features four high-field NMR instruments, including 800 and shielded 900 MHz systems. The instruments are used to study the structures and dynamics of both proteins and nucleic acids at the atomic level, and for probing the formation of biologically important molecular complexes and their functions.

QB3/College of Chemistry Mass Spectrometry Facility
The QB3/College of Chemistry Mass Spectrometry Facility is currently located in 8 Lewis Hall but will soon move to B207 Stanley Hall. The facility features state-of-the-art mass spectrometers. It provides routine nominal and accurate mass measurements of biological, organic and inorganic compounds as well as structural elucidation through tandem mass spectrometry. Mass spectral proteomics analysis, mass measurement of intact proteins, lipids, oligosaccharides, and non-covalent protein-protein and protein-ligand complexes are also available.

QB3 Macrolab
Directed by Professor James Berger and managed by Scott Gradia, this Stanley Hall facility offers automated liguid-handling services to enable high-throughput analysis in several key areas. Services are available in 1) cloning and mutagenesis, 2) protein expression and purification, and 3) protein crystallization reagents and other useful consumables.

Genomics and Proteomics

Vincent J. Coates Genomics Sequencing Laboratory
Faculty Advisors: Michael B. Eisen, Associate Professor of Genetics and Development, and Rachel Brem, Assistant Professor of Genetics and Development. Managed by Leath Tonkin, Ph.D. Established by a generous gift of the Vincent J. Coates Foundation. The facility in Stanley Hall is equipped with a Solexa 1G Genome Analyzer to exploit massively paralleled sequencing for genome sequencing, ChIP sequencing, small RNA discovery, and expression profiling.

Vincent J. Coates Proteomics/Mass Spectrometry Laboratory
The proteomics / mass spectrometry laboratory (P/MSL) offers full services in protein identification and characterization. These services include protein identification from complex samples through MudPIT analysis, post-translational modification analysis, and identification of proteins from gel bands.

Imaging

QB3/College of Chemistry Mass Spectrometry Facility
The QB3/College of Chemistry Mass Spectrometry Facility is currently located in 8 Lewis Hall but will soon move to B207 Stanley Hall. The facility features state-of-the-art mass spectrometers. It provides routine nominal and accurate mass measurements of biological, organic and inorganic compounds as well as structural elucidation through tandem mass spectrometry. Mass spectral proteomics analysis, mass measurement of intact proteins, lipids, oligosaccharides, and non-covalent protein-protein and protein-ligand complexes are also available.

Bioengineering

Biomolecular Nanotechnology Center
Directed by UC Berkeley professors Luke Lee, Dorian Liepmann, and Richard Mathies, the Biomolecular Nanotechnology Center (BNC) is a 11,500 sq ft class 1,000/10,000 cleanroom facility located in Stanley Hall. Once it is fully equipped, the BNC will feature a full range of lithography, deposition, etching, metrology, and microscopy equipment as well as facilities for performing biological experiments. The center focuses on microfluidic processing of glass and polymer materials. Experimentation on proteins, nucleic acids, cells, and tissues are encouraged. In addition to a state-of-the-art research lab, the center also features a teaching lab for hands-on training of both undergraduate and graduate students.