In 2015, QB3 partnered with Calico to make discoveries that will translate into a better understanding of the biology of aging and potential therapies for age-related diseases. Our partnership includes a broad sponsored research agreement and a grant mechanism to support innovation in longevity research led by QB3. Read the press release
Last year we processed applications for the first round of Longevity Fellowships. These Fellowships provide funding for a longevity-focused project in the form of a grant of $120K per year for two years. Each postdoc funded by the project becomes a Longevity Fellow, and joins QB3 workshops and symposia focused on aging research. These are joint events with Calico, and they provide opportunities to develop relationships with other program participants and with Calico scientists.
There are three areas of interest for the Longevity Fellowships:
- Developing a molecular/quantitative measure of aging, and in particular a measure of the rate of cognitive decline
- New therapeutic strategies for aging or age-related diseases
- Strategies to measure drug efficacy for neurodegenerative disease
cancer cell map initiative (UCSF/UCSD)
Biomedical research in the 21st century will depend increasingly on insights gained from network interaction studies: understanding the complex, multifunctional relationships between molecules, structures and processes within a cell that give rise to all of its normal and diseased behaviors. The Cancer Cell Map Initiative (CCMI) is harnessing this new approach to catalyze a major phase transition in cancer research, toward network-based precision medicine.
The CCMI was co-founded in 2016 by Nevan Krogan, the director of QBI, QB3's research arm at UCSF, and Trey Ideker, chief of medical genetics in the UC San Diego Department of Medicine and founder of the UC San Diego Center for Computational Biology & Bioinformatics.
Global alliance for genomes and health
The purpose of the international not-for-profit Global Alliance for Genomics and Health (Global Alliance), co-founded by QB3-UCSC director David Haussler in 2013, is to realize the full potential of precision medicine by advancing a common framework of harmonized approaches designed to enable effective and responsible sharing of genomic and clinical data.
In just two years, the Global Alliance has produced a variety of initiatives that facilitate data discovery and knowledge exchange, including our Genomics API, which enables the sharing of genotype and phenotype information across diverse international platforms; the Beacon Network, which provides a global search engine to facilitate data discovery across patient and control cohorts, curated databases, and the scientific literature; the BRCA Exchange, which provides expert, curated classification of variants in the cancer susceptibility genes, BRCA1 and BRCA2; the Matchmaker Exchange, a federated platform that enables researchers to match rare disease cases with similar phenotypic and genotypic profiles from around the world to assist with diagnosis and treatment decisions; the Framework for Responsible Sharing of Genomic and Health-Related Data, a document produced by our Regulatory and Ethics Working Group, which provides foundational principles for responsible data sharing and has been translated into 12 languages; a Security Infrastructure document produced by our Security Working Group recommends policy and technology approaches for stakeholders in the data sharing ecosystem.